A serious concern due to iron toxicity is Hemosiderosis, which is when the body has too much iron storage. Chronic hemosiderosis is known as hemochromatosis, this allows more dietary iron to be absorbed than usual. Once iron is absorbed, there is no physiologic mechanism for excretion of excess iron from the body other than blood loss (i.e., pregnancy, menstruation or other bleeding) and desquamated cells. With no excretion the normal amount of iron, approximately 1-2 mg, is used or lost by desquamated epithelia. Hence, any excess iron above 2 mg is literally trapped in the body. When iron absorption exceeds the storage capacity of ferritin molecules, unbound iron may promote free-radical formation in cells, resulting in membrane lipid peroxidation and cellular injury. This resulting iron over-load can seriously damage and impair major tissues of the body such as: the liver and the heart. It can also result in diabetes, arthritis, and discoloration of the skin. The majorities that are subject to these kinds of toxicities are: men, chronic excessive alcohol consumers, and individuals that are genetically at risk for hemochromatosis. The reasoning being men usually consume more iron, and they do not loss blood monthly by menstruation. Chronic alcohol abusers usually have an impaired liver which may result in a hyper-absorption of iron. Those who have a genetic risk for hemochromatosis have excess iron build up over the span of many years. After several decades of increased iron absorption non-specific symptoms (i.e., fatigue, weakness, arthralgia) develop, followed by advanced conditions (i.e., arthritis, cirrhosis, liver cancer). Symptoms usually appear after 15–20 g of iron has accumulated in the body. Those who are genetically prone may suffer from complications of and HFE gene mutation. The HFE gene codes for a transmembrane glycoprotein that modulates iron uptake. This protein is highly expressed in intestinal cells at the site of dietary iron absorption. Recent studies suggest that loss of a functional HFE protein leads to increased iron uptake in the intestinal epithelial cell, which results in increased dietary iron absorption.
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We had Jack's ultrasound done on June 4th. Column 1: baby's face, it's a boy!, and profile. Column 2: Legs and arms, curled into a ball feet over head and kissing knees, another view curled up. It was so fun to see him. He was constantly curled into a little ball, he didn't want to stretch out.
The beginning of the twelfth century marked the clearance and survival of the first millennium. Prior to the millennium much fear was generated of the second coming and the end of life. After the survival, a mass religious rebirth spawned. This included a wave of faith and pilgrimage, and undertaking to remove the Muslims, and more intensive religi
ous activity. Hence, an enormous amount of churches and cathedrals were built to house pilgrims. Unfortunately the religious outlook was somewhat pessimistic, and dark. This is best displayed in Last Judgment, a tympanum on the Saint Lazare Cathedral at
During the Gothic period the religious atmosphere seemed to lighten up, and an overall optimistic perspective o
n religion, a true revival. The early gothic style is fashioned in Beau Dieu, a trumeau statue of the central doorway on the west façade, of the Amiens Cathedral. Here the idea is seen as a loving beautiful God. Christ is the old pantacrator, giving the blessing gesture. Although he is still not contrapossto, Christ does seem to be more open and contain expression and meaning in comparison to Romanesque. But a sculpture that more fully emphasizes the expression of art and learning during the Gothic period is the Virgin and Child of Notre Dame. Mary is sculpted as the Queenly M
adonna and is dressed with the appearance of a French queen. Her body is more relaxed and is elongated with a hip thrust to support Christ, also know as the gothic sway. She serves as an important symbol of guidance and protection. This all shows the more loving delightful positive feeling of religion, and how art was used in a positive way to enhance learning and security. This statue shows more expressive feeling and is also more convincing.
Moving into the Renaissance we can see a great leap of innovation once again. With Donatello’s David, we see that the relaxed classical contrapposto stance has been rediscovered; also his proportions are of Greek origin. Most importantly is that David is the first 
nude figure since ancient times. This specific nudity is seen as bold and heroic, not frail and vulnerable like before. His body shows hints of anatomical interest. While the story of David and Goliath is biblical, David is also a symbol of the independent Florentine republic. This statue shows many of the details and expression of the renaissance, ar
tists were once again using art to evoke the senses, while still having political and religious value. In the High renaissance Michelangelo’s David, is as captivating as Ancient Greek and Ancient Roman sculpture. Although larger than life his nude body shows understanding of movement and anatomy. His emotion is in his body and his Hellenistic looking face. This evokes the senses and awareness of what he is doing and what he might be seeing.
Into the seventeenth century we can now experience baroque art. By now all technique is mastered, and artists are involved in involving the viewer. In Gernini’s The Ecstasy of Saint Teresa, our senses are evoked by the technique of using other sources of lighting, the rods of light coming with the angel and the sensation that the sculpture is hovering. We ourselves our wrapped up as if in Teresa’s drapery and can understand the sense of some kind of erotic emotion. Bernini has blurred the lines of seeing a real view point, it is not ideal because what matters is the viewer.
Overall, the length from the Romanesque to the baroque is remarkable. A complete revival of the senses, statues move from solely being a religious and rigid use, to being provocative, incredible technique, and used in learning and teaching as well.
